Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

alpha-Cyclodextrin/oil beads: an innovative self-assembling system.

A Bochot1, L Trichard, G Le Bas

  • 1Univ Paris-Sud; CNRS UMR8612; Physico-chimie - Pharmacotechnie - Biopharmacie, Faculté de Pharmacie, 5 rue JB Clément, Châtenay-Malabry F-92296, France. amelie.bochot@u-psud.fr

International Journal of Pharmaceutics
|April 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunotoxicity of poly (lactic-co-glycolic acid) nanoparticles: influence of surface properties on dendritic cell activation.

Nanotoxicology·2019
Same author

Protection against Clostridium difficile infection in a hamster model by oral vaccination using flagellin FliC-loaded pectin beads.

Vaccine·2018
Same author

Parameters for Stable Water-in-Oil Lipiodol Emulsion for Liver Trans-Arterial Chemo-Eembolization.

Cardiovascular and interventional radiology·2017
Same author

Source-receptor probability of atmospheric long-distance dispersal of viruses to Israel from the eastern Mediterranean area.

Transboundary and emerging diseases·2017
Same author

Using Synoptic Systems' Typical Wind Trajectories for the Analysis of Potential Atmospheric Long-Distance Dispersal of Lumpy Skin Disease Virus.

Transboundary and emerging diseases·2015
Same author

In vivo evaluation of paclitaxel-loaded lipid nanocapsules after intravenous and oral administration on resistant tumor.

Nanomedicine (London, England)·2015
Same journal

Artificial intelligence and CRISPR-based approaches for targeted delivery of bacteriophages.

International journal of pharmaceutics·2026
Same journal

A "three-in-one" nose-to-brain delivery strategy: intranasal vancomycin spray achieves simultaneous clearance of pneumococcal colonization, bacteremia, and meningitis.

International journal of pharmaceutics·2026
Same journal

10-Hydroxy-2-decenoic acid /matrine deep eutectic solvent encapsulated in hyalurosomes for enhanced transdermal delivery and antioxidant efficacy.

International journal of pharmaceutics·2026
Same journal

Dual-trigger hyaluronic acid nanoprodrug incorporating a 2-nitrobenzenesulfonyl linker for CD44-targeted and glutathione-responsive drug delivery.

International journal of pharmaceutics·2026
Same journal

Polymeric mixed micellar nanogel enhances dermal delivery and therapeutic efficacy of tofacitinib citrate.

International journal of pharmaceutics·2026
Same journal

Localized gold nanoparticles-mediated photothermal therapy for head and neck cancer: in vivo proof-of-concept.

International journal of pharmaceutics·2026
See all related articles

Researchers developed novel, solvent-free particulate beads using alpha-cyclodextrin and soybean oil. These stable, microencapsulated beads show promise for pharmaceutical and cosmetic applications.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Sciences

Background:

  • Developing effective microencapsulation systems is crucial for protecting sensitive molecules.
  • Traditional methods often rely on organic solvents or surfactants, posing environmental and safety concerns.
  • Novel particulate systems are needed for improved delivery of lipophilic compounds.

Purpose of the Study:

  • To characterize a new particulate system, termed beads, for microencapsulation.
  • To investigate the formation mechanisms of these alpha-cyclodextrin and soybean oil-based beads.
  • To evaluate the potential of these beads for pharmaceutical and cosmetic applications.

Main Methods:

  • Beads were prepared using a straightforward technique involving alpha-cyclodextrin aqueous solution and soybean oil.

Related Experiment Videos

  • Optimal formulation ratios were determined through systematic experimentation.
  • Characterization involved X-ray diffraction, microscopy, and quantification of oil and alpha-cyclodextrin content after freeze-drying.

    • Main Results:

    • An optimal ratio of 6% alpha-cyclodextrin, 19.6% soybean oil, and 74.4% water yielded homogeneous beads (1.6 mm) with over 80% fabrication yield.
    • Freeze-dried beads contained approximately 80% oil and 20% alpha-cyclodextrin.
    • X-ray diffraction confirmed a crystalline organization, and microscopy revealed an inner matrix with oily compartments.

    Conclusions:

    • The developed beads represent a novel, solvent-free particulate system for microencapsulation.
    • Their composition and structure make them suitable for encapsulating lipophilic and unstable molecules.
    • The beads demonstrate significant potential for oral and topical pharmaceutical formulations, as well as cosmetic applications.