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Updated: Jul 15, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus
Jong-Gyo Lee1, Ick-Dong Yoo, Won-Gon Kim
1Pharmacology Research Center, Korea Research Institute of Chemical Technology, Korea.
Abstract:
Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC50 values of 1.92, 0.53, and 1.99 microg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.
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