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Autoimmune pancreatitis with extreme elevation of DUPAN-2

Shiho Mishima1, Yohei Mizuta, Takuji Yamao

  • 1Department of Internal Medicine, Nagasaki Municipal Hospital, Nagasaki, Japan.

Internal Medicine (Tokyo, Japan)
|April 6, 2007
PubMed

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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