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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: Jul 15, 2026

Mongolian Gerbils as an Animal Model of Wound Healing
07:54

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

Central corneal thickness in pediatric glaucoma.

João E Lopes1, Richard R Wilson, Heryberto S Alvim

  • 1Oncology Service; Wills Eye Hospital, Philadelphia, Pennsylvania 19107, USA.

Journal of Pediatric Ophthalmology and Strabismus
|April 7, 2007
PubMed
Summary

Children with glaucoma have thicker corneas (central corneal thickness or CCT) than those without. This CCT significantly impacts intraocular pressure (IOP) measurements, affecting diagnosis and management in pediatric glaucoma patients.

Related Experiment Videos

Last Updated: Jul 15, 2026

Mongolian Gerbils as an Animal Model of Wound Healing
07:54

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology

Background:

  • Pediatric glaucoma diagnosis and management can be challenging.
  • Intraocular pressure (IOP) is a key metric, but its accuracy can be influenced by central corneal thickness (CCT).

Purpose of the Study:

  • To compare central corneal thickness (CCT) in children with and without glaucoma.
  • To assess the impact of CCT on intraocular pressure (IOP) measurements in pediatric glaucoma.

Main Methods:

  • Central corneal thickness (CCT) and intraocular pressure (IOP) were measured in children with and without glaucoma.
  • Exclusion criteria included corneal edema or scarring.
  • IOPs in the pediatric glaucoma group were adjusted using a linear algorithm based on CCT.

Main Results:

  • Children with glaucoma exhibited significantly higher mean CCT (610.2 µm) compared to controls (555.6 µm).
  • CCT varied significantly across different pediatric glaucoma diagnoses (e.g., primary congenital glaucoma, Sturge-Weber syndrome, aphakic glaucoma, aniridia, microcornea).
  • Clinically significant IOP overestimation (≥3 mm Hg) occurred in 41.2% of eyes, and underestimation in 14.7% after CCT adjustment.

Conclusions:

  • Pediatric glaucoma patients generally have increased CCT compared to non-glaucoma controls.
  • CCT significantly influences IOP measurements in over half of pediatric glaucoma cases.
  • Pachymetry (CCT measurement) is crucial for accurate IOP assessment and management in children with glaucoma.