Related Experiment Video
Updated: Jul 15, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Presumed stromal graft rejection after automated lamellar therapeutic keratoplasty: case report
Motoko Kawashima1, Hiroshi Mochizuki, Tetsuya Kawakita
1Department of Ophthalmology, Tokyo Dental College, Chiba, Japan. motokok@tdc.ac.jp.
Purpose:
To describe the development of presumed immune-mediated stromal rejection after automated lamellar therapeutic keratoplasty (ALTK) and its reversal after initiation of intensive topical corticosteroid therapy.
Methods:
Observational case report.
Results:
Stromal edema localized in the graft developed 42 days after ALTK for Avellino corneal dystrophy in a 65-year-old man. After one week of intensive topical corticosteroids, complete reversal of graft edema occurred, with full recovery of visual function.
Conclusion:
The clinical appearance and response to therapy in this case supported the diagnosis of immune-mediated stromal rejection. Ophthalmologists should be aware that stromal rejection may occur in lamellar corneal grafts.
