Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Initial 5-fluorouracil trabeculectomy in young patients.

J Whiteside-Michel1, J M Liebmann, R Ritch

  • 1Department of Ophthalmology, New York Eye and Ear Infirmary, NY 10003.

Ophthalmology
|January 1, 1992
PubMed
Summary

Initial trabeculectomy combined with 5-fluorouracil (5-FU) effectively lowers intraocular pressure (IOP) in young glaucoma patients. This treatment achieved a 95% success rate in reducing IOP without medication in a recent study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal nerve fiber layer loss in pigment dispersion syndrome.

European journal of ophthalmology·2017
Same author

Nailfold capillary morphology in exfoliation syndrome.

Eye (London, England)·2017
Same author

A New Provocative Test for Glaucoma.

Journal of current glaucoma practice·2016
Same author

Arcuate scotoma associated with traction at the optic disc.

Eye (London, England)·2013
Same author

Artificial vision.

Panminerva medica·2011
Same author

Baseline mean deviation and rates of visual field change in treated glaucoma patients.

Eye (London, England)·2011

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Ocular Oncology

Background:

  • Glaucoma in patients under 40 presents unique management challenges.
  • Trabeculectomy is a standard surgical procedure for glaucoma.
  • 5-fluorouracil (5-FU) is an antimetabolite used as an adjunctive agent in glaucoma surgery.

Purpose of the Study:

  • To evaluate the long-term effectiveness of initial trabeculectomy with 5-fluorouracil (5-FU) in patients aged 40 or younger.
  • To assess the safety and efficacy of this combined surgical approach for various types of glaucoma in young individuals.

Main Methods:

  • Retrospective analysis of 20 eyes from 20 patients (age 13-40) undergoing initial trabeculectomy with 5-FU.
  • Patients included those with juvenile primary open-angle glaucoma, pigmentary glaucoma, and glaucoma with angle recession.

Related Experiment Videos

  • Mean follow-up duration was 31.1 months.

    • Main Results:

    • Postoperative intraocular pressure (IOP) significantly decreased from a mean of 34.4 mmHg to 10.5 mmHg.
    • 95% of eyes achieved an IOP of 20 mmHg or less without additional medication.
    • Complications included two cases of bleb-related endophthalmitis and one case of hypotony maculopathy.

    Conclusions:

    • Initial trabeculectomy with adjunctive 5-FU is a highly effective treatment for lowering IOP in young patients with uncomplicated glaucoma.
    • The procedure demonstrates a high success rate in achieving target IOP goals, with a low rate of serious complications.