Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Psoriasis--a possible candidate for vaccination.

Lionel Fry1, Barbara S Baker, Anne V Powles

  • 1Faculty of Medicine, Imperial College, London W2 1PG, United Kingdom. l.fry@imperial.ac.uk

Autoimmunity Reviews
|April 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a charity-led secondary breast cancer support day: a model of survivorship care.

Ecancermedicalscience·2020
Same author

Psoriasis is not an autoimmune disease?

Experimental dermatology·2014
Same author

A randomised controlled pilot feasibility study of the physical and psychological effects of an integrated support programme in breast cancer.

Complementary therapies in clinical practice·2012
Same author

Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia.

PLoS neglected tropical diseases·2012
Same author

Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin.

Archives of dermatological research·2011
Same author

Evidence for the presence of bacteria in the blood of psoriasis patients.

Archives of dermatological research·2010

Streptococcal infections are linked to psoriasis. New findings show T cells in psoriasis skin react to streptococcal peptidoglycan, suggesting a new pathway for adaptive immune responses and potential psoriasis vaccines.

Area of Science:

  • Immunology
  • Dermatology
  • Microbiology

Background:

  • The connection between streptococcal infections and psoriasis is a recognized clinical observation.
  • Recent research indicates T cells within psoriasis skin lesions exhibit reactivity towards streptococcal peptidoglycan.

Purpose of the Study:

  • To explore the immunological pathway linking streptococcal infections to psoriasis.
  • To investigate the role of T cell response to streptococcal peptidoglycan in psoriasis pathogenesis.
  • To assess the potential for developing novel therapeutic strategies, such as vaccines, for psoriasis.

Main Methods:

  • Analysis of T cell responses in psoriasis skin.
  • Identification of specific antigens targeted by T cells in affected skin.
  • Immunological assays to confirm T cell reactivity to streptococcal components.

Related Experiment Videos

Main Results:

  • Demonstrated that T cells infiltrating psoriasis skin recognize streptococcal peptidoglycan.
  • Established a potential adaptive immune response pathway involving streptococcal antigens.
  • Provided evidence for a molecular link between streptococcal exposure and psoriasis development.

Conclusions:

  • The findings suggest that T cell recognition of streptococcal peptidoglycan is a key factor in the immune response driving psoriasis.
  • This understanding opens avenues for developing targeted vaccines or immunotherapies for psoriasis based on streptococcal antigens.