Jove
Visualize
Contact Us

Related Experiment Videos

Circumscribed acral hypokeratosis.

David R Berk1, Almut Böer, Fred D Bauschard

  • 1Division of Dermatology, Washington University School of Medicine, St Louis, MO 63110, USA. DBerk@im.wustl.edu

Journal of the American Academy of Dermatology
|April 7, 2007
PubMed
Summary

Circumscribed acral hypokeratosis (CAH) can affect palms and soles, appearing as single or multiple lesions. This condition may be a reaction to stimuli like trauma or human papillomavirus (HPV).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term treatment of atopic dermatitis with roflumilast cream 0.15% in patients aged 6 years or older (INTEGUMENT-OLE clinical study): a plain language summary.

The Journal of dermatological treatment·2026
Same author

Roflumilast foam versus vehicle foam for seborrheic dermatitis (STRATUM clinical study): a plain language summary.

The Journal of dermatological treatment·2026
Same author

Long-Term Safety and Efficacy of Once-Daily and Proactive Twice-Weekly Roflumilast Cream 0.05% for Mild-to-Moderate Atopic Dermatitis in Children Aged 2-5 Years From a 52-Week, Phase 3 Trial (INTEGUMENT-OLE).

Pediatric dermatology·2026
Same author

Long-Term Safety and Efficacy of Roflumilast Foam 0.3% in Patients with Seborrheic Dermatitis: A Phase II, Open-Label Trial of up to 52 Weeks.

American journal of clinical dermatology·2025
Same author

Roflumilast Cream 0.3% in Patients with Chronic Plaque Psoriasis: Pooled PASI and PASI-HD Results from the DERMIS Phase III Trials.

Dermatology and therapy·2025
Same author

Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in Children Aged 2-11 Years.

Pediatric dermatology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Circumscribed acral hypokeratosis (CAH) is an idiopathic condition presenting as a solitary, well-defined, depressed deformity on the palm or sole, with a characteristic histological appearance.
  • The lesional epidermis in CAH is depressed with an abrupt, hyperkeratotic, slightly-raised ridge at the normal skin border.

Observation:

  • This study presents three additional cases of circumscribed acral hypokeratosis (CAH).
  • Case history details include prior trauma (burn) or verruca plantaris in the affected location for two patients.
  • Lesion presentation varied, with solitary lesions on the palm or sole in two cases and multiple lesions on both palms and soles in one case.

Findings:

  • Human papillomavirus (HPV) type 6 was detected in one patient with a history of warts in the same location.

Related Experiment Videos

  • Standard treatments including topical fluorouracil, calcipotriol, and clobetasol were unsuccessful in one patient.
  • Histological examination revealed a depressed epidermis with a hyperkeratotic ridge at the lesion border.

    • Implications:

    • Circumscribed acral hypokeratosis (CAH) can manifest as solitary or multiple lesions on the palms and/or soles.
    • The findings suggest CAH may represent a reactive pattern to various stimuli, potentially including trauma and/or HPV infection.
    • Further research is warranted to elucidate the etiology and optimal management of CAH.