Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation in experimental and human temporal lobe epilepsy.

E Aronica1, K Boer, E A van Vliet

  • 1Department of (Neuro) Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.

Neurobiology of Disease
|April 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial protein expression patterns across pathologically-associated fibers revealed molecular specialization in inclusion body myositis.

Cell communication and signaling : CCS·2026
Same author

Reply: Muscle abnormalities in Long COVID.

Nature communications·2025
Same author

Brain tumour diagnostics using a DNA methylation-based classifier as a diagnostic support tool.

Neuropathology and applied neurobiology·2020
Same author

Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14.

Neuropathology and applied neurobiology·2019
Same author

Chronic activation of anti-oxidant pathways and iron accumulation in epileptogenic malformations.

Neuropathology and applied neurobiology·2019
Same author

Response to: Diagnostic value of additional histopathological fascia examination in idiopathic inflammatory myopathies.

European journal of neurology·2019
Same journal

Loss of immunological control at CD28 superfamily checkpoints links brain and peripheral immunity to depressive-like behaviors in animal models.

Neurobiology of disease·2026
Same journal

Investigating tau-related white matter degeneration in Alzheimer's disease using fixel-based analysis.

Neurobiology of disease·2026
Same journal

Evidence for hippocampal globotriaosylceramide (Gb3) accumulation and spatial memory impairment in a mouse model of Fabry disease.

Neurobiology of disease·2026
Same journal

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy.

Neurobiology of disease·2026
Same journal

GDAP1 orchestrates redox signaling at membrane contact sites to preserve axonal integrity in Charcot-Marie-Tooth disease.

Neurobiology of disease·2026
Same journal

Tier-specific location of Lewy body pathology and related neuromelanin levels drive dopaminergic cell vulnerability in pigmented non-human primates.

Neurobiology of disease·2026
See all related articles

The complement cascade is activated in temporal lobe epilepsy (TLE). Complement proteins like C1q and C3 are upregulated in rats and humans with TLE, suggesting a role in chronic epilepsy and neuronal damage.

Area of Science:

  • Neuroscience
  • Immunology

Background:

  • Epileptogenesis involves complex molecular changes.
  • The complement cascade, a part of the immune system, plays a role in neuroinflammation.

Purpose of the Study:

  • To investigate the role of the complement cascade in temporal lobe epilepsy (TLE).
  • To examine complement activation in both experimental rat models and human TLE.

Main Methods:

  • Gene expression analysis (microarrays, qPCR) in rat models.
  • Protein expression analysis (immunohistochemistry) in rat and human TLE tissues.
  • Analysis of complement components C1q, C3, C4, and C5b-C9.

Main Results:

  • Classical complement pathway activation was observed in rats post-status epilepticus (SE).

Related Experiment Videos

  • Increased C1q, C3, and C4 expression was confirmed in rat hippocampus.
  • Complement proteins were detected in microglia, neurons, and astrocytes in both rat and human TLE, particularly in areas of neuronal loss.

    • Conclusions:

    • Complement cascade activation is involved in epileptogenesis and chronic TLE.
    • Persistent complement activation may contribute to sustained neuroinflammation and neuronal network destabilization in TLE.