Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive functioning in the schizophrenia prodrome.

Andor E Simon1, Katja Cattapan-Ludewig, Solange Zmilacher

  • 1Department of Psychiatry, Specialized Outpatient Service for Early Psychosis, Psychiatric Outpatient Services, 4104 Bruderholz, Switzerland. andor.simon@tiscalinet.ch

Schizophrenia Bulletin
|April 7, 2007
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linking human brain functional connectivity to underlying neurotransmission.

bioRxiv : the preprint server for biology·2026
Same author

A Phase 2b Multicenter Study to Evaluate Basmisanil as an Adjunctive Treatment in Patients With Cognitive Impairment Associated With Schizophrenia.

The Journal of clinical psychiatry·2026
Same author

A novel psychedelic 5-HT<sub>2A</sub> receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer.

Journal of psychopharmacology (Oxford, England)·2025
Same author

Relapse in Schizophrenia: A Systematic Review of Criteria for Clinical Studies and International Consensus Guidelines to Improve Them.

The American journal of psychiatry·2025
Same author

Using the grip strength effort task to measure reward processing dysfunction in schizophrenia and major depressive disorder.

Neuroscience applied·2025
Same author

N-chlorotaurine does not alter structural tendon properties: a comparative biomechanical study.

Archives of orthopaedic and trauma surgery·2025

Cognitive impairments in schizophrenia are present early. Individuals at ultra high-risk (UHR) and those with basic symptoms (BS) show intermediate cognitive deficits, supporting early intervention for schizophrenia.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Cognitive alterations are increasingly recognized in early schizophrenia.
  • Understanding cognition in at-risk states is crucial for early intervention models.

Purpose of the Study:

  • To investigate cognitive functioning in individuals meeting basic symptom (BS) or ultra high-risk (UHR) criteria for schizophrenia.
  • To compare cognitive performance across different stages of psychosis trajectory.

Main Methods:

  • Cognitive assessment of 93 individuals meeting BS or UHR criteria.
  • Comparison with 43 first-episode psychosis patients and 49 controls.
  • Analysis of auditory working memory, verbal fluency, processing speed, and declarative memory.

Related Experiment Videos

Main Results:

  • All groups performed below normative values.
  • Both BS and UHR groups showed intermediate cognitive performance between first-episode patients and controls.
  • The UHR group performed between the first-episode and BS groups.

Conclusions:

  • Cognitive impairments in early schizophrenia prodrome may be modest.
  • Findings support early intervention to prevent psychosis onset and further cognitive damage.
  • Auditory working memory, verbal fluency/processing speed, and declarative memory are most affected.