Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Target-specific PIP(2) signalling: how might it work?

Nikita Gamper1, Mark S Shapiro

  • 1Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. n.gamper@leeds.ac.uk

The Journal of Physiology
|April 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small peptides derived from the autoinhibitory XY linker of phospholipase C-β isoforms inhibit enzyme activity and reduce inflammation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Improving K<sub>v</sub>7 targeting anticonvulsants - will repurposing save the day?

British journal of pharmacology·2025
Same author

Elucidation of the zinc binding site in KCNQ channels.

British journal of pharmacology·2025
Same author

Peripheral Gating of Nociception Investigated with a Decerebrate, Arterially Perfused Preparation of the Rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat.

The EMBO journal·2025
Same journal

Diving exposure and pulmonary stress.

The Journal of physiology·2026
Same journal

Systems modelling of mitochondrial dynamics in different exercise regimes.

The Journal of physiology·2026
Same journal

Central leptin resistance precedes obesity and drives early endocrine dysfunction.

The Journal of physiology·2026
Same journal

Decoding the molecular memory of obesity using machine learning and microRNA dynamics.

The Journal of physiology·2026
Same journal

Kinematic-calcium loops unravel impaired excitation-contraction coupling in MELAS-affected cardioids.

The Journal of physiology·2026
Same journal

hERG1 channels and potential therapeutics for long QT syndrome.

The Journal of physiology·2026
See all related articles

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) signaling specificity is achieved through membrane microdomain clustering or calcium-mediated buffering. These mechanisms explain how cells regulate diverse PIP(2)-sensitive proteins.

Area of Science:

  • Cellular signal transduction
  • Membrane biology
  • Molecular signaling pathways

Background:

  • Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a key signaling lipid regulating numerous cellular processes.
  • A growing number of PIP(2)-sensitive proteins, including ion channels and transporters, are being identified.
  • Understanding the specificity of PIP(2)-mediated signaling is crucial due to its widespread cellular roles.

Purpose of the Study:

  • To critically evaluate proposed mechanisms conferring specificity to PIP(2)-mediated signaling.
  • To explore the roles of membrane microdomains and calcium signaling in regulating PIP(2) availability.
  • To discuss complexities in studying PIP(2) signaling.

Main Methods:

  • Literature review and critical analysis of existing hypotheses.

Related Experiment Videos

  • Discussion of experimental evidence supporting different models.
  • Conceptual analysis of PIP(2) dynamics and regulation.

    • Main Results:

    • Two primary hypotheses for PIP(2) signaling specificity are presented: PIP(2) clustering in microdomains and receptor-specific buffering via calcium.
    • PIP(2) clustering offers spatial segregation of signals.
    • Calcium-mediated buffering allows for receptor-specific signaling with free PIP(2) diffusion.

    Conclusions:

    • PIP(2) signaling specificity is likely achieved through distinct cellular mechanisms, including spatial organization and dynamic regulation.
    • Further research is needed to fully elucidate the interplay of these mechanisms.
    • Addressing technical and conceptual challenges is vital for advancing the field of PIP(2) signaling.