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Updated: Jun 25, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Imaging-guided microarray: isolating molecular profiles that dissociate Alzheimer's disease from normal aging.

Ana Carolina Pereira¹, William Wu, Scott A Small

¹Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Annals of the New York Academy of Sciences

|April 7, 2007

Summary

This summary is machine-generated.

Alzheimer's disease and normal aging cause hippocampal dysfunction via distinct molecular pathways. Imaging-guided microarray helps identify these specific molecular differences in the brain.

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Area of Science:

Neuroscience
Molecular Biology
Biomedical Imaging

Background:

Alzheimer's disease (AD) and normal aging both impair hippocampal function.
Distinct molecular mechanisms likely underlie these age-related changes.
Analyzing brain disorders with gene expression profiling presents analytical challenges.

Purpose of the Study:

To review functional magnetic resonance imaging (fMRI) findings differentiating AD and normal aging.
To explore preliminary imaging-guided microarray data in AD and normal aging.
To identify molecular profiles distinguishing AD from normal aging-related hippocampal dysfunction.

Main Methods:

Review of functional magnetic resonance imaging (fMRI) studies in AD and normal aging.
Application of imaging-guided microarray techniques to brain tissue.
Analysis of spatiotemporal and molecular profiles.

Main Results:

fMRI reveals distinct spatiotemporal patterns for AD and normal aging.
Preliminary imaging-guided microarray data show potential for molecular differentiation.
Specific molecular profiles may dissociate AD from normal aging in the hippocampus.

Conclusions:

Functional magnetic resonance imaging (fMRI) can distinguish between Alzheimer's disease and normal aging.
Imaging-guided microarray offers a promising approach to uncover molecular differences.
Understanding these distinct mechanisms is crucial for addressing age-related hippocampal dysfunction.