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Published on: December 2, 2015
Parent-of-origin effect in the segregation analysis of bipolar affective disorder families
Tsuo-Hung Lan1, Terri H Beaty, J Raymond DePaulo
1Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Objective:
The purpose of this study is to test for heterogeneity in bipolar families based on the differential parental transmission of disease.
Methods:
Complex segregation analyses of 260 bipolar families, ascertained by the Johns Hopkins Bipolar Disorder Study, was performed based on the evidence for a parent-of-origin effect in the inheritance pattern by using REGD in Statistical Analysis for Genetic Epidemiology, Release 3.1 program.
Results:
A Mendelian dominant model provided the best explanation in 57 paternal pedigrees (pedigrees with an affected paternal lineage). No evidence of Mendelian inheritance existed among 141 pedigrees showing maternal transmission. A likelihood ratio test for heterogeneity on the basis of best-fitting Mendelian dominant model showed significant differences between these two groups.
Conclusion:
These results suggest that pedigrees with no evidence of maternal transmission of bipolar disorder may represent a unique genetic subgroup of multiplex bipolar families.
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