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Related Experiment Video

Updated: Jul 15, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Corneal thickness at high altitude.

Daniel S Morris1, John E A Somner, Kirsten M Scott

  • 1Sunderland Eye Infirmary, Sunderland, United Kingdom. danielsmorris@hotmail.com

Cornea
|April 7, 2007
PubMed
Summary

High altitude exposure significantly increases central corneal thickness (CCT) in lowlanders. This corneal swelling may affect vision for mountaineers and those who have had refractive surgery.

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Last Updated: Jul 15, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Area of Science:

  • Ophthalmology
  • Altitude Physiology
  • Environmental Medicine

Background:

  • High altitude environments present physiological challenges, including hypobaric hypoxia.
  • Corneal swelling is a known response to hypoxia at sea level, such as with contact lens wear.

Purpose of the Study:

  • To investigate the impact of high altitude on central corneal thickness (CCT) in lowlanders.
  • To quantify changes in CCT during ascent and acclimatization to high altitude.

Main Methods:

  • Ultrasound pachymetry was used to measure CCT in 63 healthy lowlanders.
  • Measurements were taken at sea level before and after the expedition, and at 5200 m (Chacaltaya, Bolivia) on days 1, 3, and 7.

Main Results:

  • Mean CCT significantly increased from 543 microm at sea level to 561 microm on day 1 at 5200 m (P < 0.001).
  • CCT continued to rise to 563 microm on day 3 and 571 microm on day 7.
  • CCT returned to baseline levels (541 microm) after returning to sea level.

Conclusions:

  • High altitude exposure causes a significant and progressive increase in CCT in healthy individuals.
  • The observed corneal swelling is likely due to endothelial dysfunction and stromal edema.
  • Potential visual disturbances may occur in high-altitude travelers, particularly those with prior refractive surgery.