Related Experiment Video
Updated: Jul 15, 2026
07:20
Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model
Published on: February 10, 2023
Intra-arterial drug delivery: a concise review
Shailendra Joshi1, Charles W Emala, John Pile-Spellman
1Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. sj121@columbia.edu
Journal of Neurosurgical Anesthesiology
|April 7, 2007
Summary
Intra-arterial drug delivery to the brain shows renewed promise due to advances in endovascular technology. Reevaluating its principles and applications is crucial for treating various brain diseases safely and effectively.
Area of Science:
- Neurology
- Pharmacology
- Neurosurgery
Background:
- Intra-arterial (IA) drug delivery to the brain was explored for brain tumors in the 1980s with limited success.
- Challenges included poor drug concentration control and risk of neurological injury, hindering wider adoption.
- Despite limitations, IA drug administration was anecdotally used for diverse brain conditions.
Purpose of the Study:
- To reevaluate the therapeutic potential of intra-arterial drug delivery to the brain.
- To review the pharmacologic principles, applications, and challenges of IA drug delivery.
- To highlight recent advancements in endovascular technology and angiography safety.
Main Methods:
- Literature review focusing on pharmacologic principles of IA drug delivery.
- Analysis of historical applications, particularly in chemotherapy for brain tumors.
- Examination of recent advances in endovascular techniques and interventional radiology.
Main Results:
- Past IA chemotherapy for brain tumors yielded modest outcomes due to control issues and safety concerns.
- Current endovascular technology and safer angiographic procedures enable a reevaluation of IA drug delivery.
- The review synthesizes knowledge on IA drug delivery's potential and limitations.
Conclusions:
- Advances necessitate a reassessment of intra-arterial drug delivery for brain conditions.
- Understanding pharmacologic principles and technical pitfalls is key to optimizing IA therapy.
- IA drug delivery holds potential for treating a spectrum of brain diseases with improved safety and efficacy.
Related Concept Videos
01:16Drug Delivery: Overview
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
01:29Drug Delivery: Parenteral Route
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
01:27Drug Delivery Systems: Different Types
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
01:21Intrauterine Drug Delivery Systems
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
01:22Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
01:18Drug Delivery: Enteral Route
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drugs in...