Related Experiment Video

Updated: Jul 15, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

Failure to respond to hepatitis B vaccine in children with celiac disease

Seung-Dae Park1, James Markowitz, Michael Pettei

  • 1Division of Pediatric Gastroenterology and Nutrition, North Shore-Long Island Jewish Health System, New Hyde Park, NY, USA. arai-k@ncchd.go.jp

Journal of Pediatric Gastroenterology and Nutrition
|April 7, 2007
PubMed

Insights

Children with celiac disease (CD) show a significantly lower response rate to the hepatitis B virus (HBV) vaccine compared to healthy children. Over half of children with CD may remain unprotected, necessitating a review of current vaccination strategies.

Area of Science:

  • Immunology
  • Pediatrics
  • Gastroenterology

Background:

  • Celiac disease (CD) is an autoimmune disorder affecting the small intestine.
  • Vaccine response in children with CD is not fully understood.
  • Hepatitis B virus (HBV) infection is a significant global health concern.

Purpose of the Study:

  • To compare the immune response to the hepatitis B virus (HBV) vaccine in children with celiac disease (CD) versus children without CD.
  • To assess vaccine response rates for other childhood vaccines (tetanus, rubella, Hib) in children with CD.

Main Methods:

  • Prospective study comparing HBV, tetanus, rubella, and Haemophilus influenzae type b (Hib) vaccine responses.
  • 26 children with CD and 18 age- and sex-matched controls were included.
  • Participants had received a full course of childhood vaccinations.

Main Results:

  • A significantly higher proportion of children with CD (53.9%) failed to respond to the HBV vaccine compared to controls (11.1%).
  • Children with CD were 8.33 times more likely to be non-responsive to HBV vaccine.
  • Response rates to rubella and tetanus vaccines were similar between groups; Hib vaccine response was also comparable.

Conclusions:

  • Over 50% of children with CD exhibit a poor response to standard HBV vaccination.
  • This indicates a substantial population of HBV-susceptible individuals with CD worldwide.
  • Current immunization protocols may require revision to ensure adequate protection against HBV in children with CD.
Abstract

More Related Videos

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...