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Updated: Jul 15, 2026

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
A metastatic melanoma with an unusual immunophenotypic profile
Zhenqiang Gao1, Albert Stanek, Sheng Chen
1Department of Pathology, Albert Einstein College of Medicine North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA.
The American Journal of Dermatopathology
|April 7, 2007
Abstract:
The most commonly used melanocytic markers are S100, HMB45, Melan-A, or MART-1 and tyrosinase. Melanoma with complete, concordant loss of these markers has not been reported. We report a case of metastatic melanoma with complete loss of staining for S100, HMB45, Melan-A, and tyrosinase. Interestingly, both the primary melanoma and its metastasis were strongly positive for CD99.
