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Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Drug-nutrient interactions in elderly people.

Dirce Akamine¹, Michel K Filho, Carmem M Peres

¹Farmoterápica, Rua Machado Bittencourt 190 conj. 206, Vila Mariana, São Paulo, SP 04044-000, Brazil. dirce.akamine@farmoterapica.com.br

Current Opinion in Clinical Nutrition and Metabolic Care

|April 7, 2007

Summary

Elderly individuals face increased risks of drug-food interactions due to multiple diseases and medications. Careful assessment and nutritional intervention are crucial to prevent adverse events in older patients.

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Area of Science:

Gerontology
Clinical Pharmacology
Nutritional Science

Background:

Elderly individuals often present with multiple comorbidities, polypharmacy, malnutrition, and altered metabolism.
These factors significantly elevate the risk of adverse drug-food interactions in the geriatric population.

Purpose of the Study:

To review considerations for elderly individuals affected by drug-food interactions.
To highlight the importance of managing drug-food interactions in older adults.

Main Methods:

Review of pharmacokinetic and pharmacodynamic modifications in the elderly.
Consideration of various factors influencing drug-food interactions, including health status, common diseases, prescribed medications, and nutritional reactions.
Specific reference to the health status of the elderly Brazilian population.

Main Results:

Factors such as anorexia, dementia, depression, gastrointestinal disorders, and reduced physical abilities impact drug-food interactions.
Common diseases in the elderly (e.g., diabetes, hypertension, dementia) and their associated drug therapies contribute to nutritional risks.
Adverse nutritional reactions are frequently observed in older patients.

Conclusions:

Accurate disease diagnosis and regular treatment re-evaluation are essential for safe drug prescription.
Minimizing the number of administered drugs and implementing appropriate nutritional assessments are key to preventing undesirable drug-food interactions.
A comprehensive approach integrating pharmacotherapy and nutritional intervention is necessary for elderly patient care.