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Related Experiment Videos

Handling elevates the colonic temperature of mice.

A Cabanac1, E Briese

  • 1Laboratory of Physiology, Université Laval, Québec, Canada.

Physiology & Behavior
|January 1, 1992
PubMed
Summary

Handling mice for temperature measurements causes a rise in colonic temperature (Tc). This stress response habituates over time and may not be true fever, as salicylate effects differ from rats.

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Area of Science:

  • Physiology
  • Animal Behavior
  • Neuroscience

Background:

  • Handling laboratory animals for physiological measurements can induce stress responses.
  • The impact of handling stress on core body temperature regulation in mice requires further investigation.
  • Understanding the distinction between stress-induced temperature changes and true fever is crucial for accurate physiological interpretation.

Purpose of the Study:

  • To investigate the effect of repeated handling on colonic temperature (Tc) in mice.
  • To explore the emotional origin and regulatory mechanisms of handling-induced Tc rise.
  • To determine if salicylate administration influences the stress-induced Tc rise in mice and compare it to findings in rats.

Main Methods:

  • Mice were subjected to repeated colonic temperature (Tc) measurements via handling.
  • Salicylate was administered to assess its effect on Tc.
  • Ear pinna temperature was monitored concurrently with Tc measurements to evaluate vasomotor responses.

Main Results:

  • Repeated handling led to a significant rise in colonic temperature (Tc), which habituated over successive days.
  • Salicylate reduced baseline and maximal Tc but did not alter the difference between initial and maximal Tc.
  • Ear pinna temperature decreased during initial Tc rise and increased as Tc plateaued, suggesting a regulated vasomotor response.

Conclusions:

  • The habituation of Tc rise indicates an emotional origin for this stress response in mice.
  • Vasomotor changes suggest that the stress-induced Tc rise is a regulated physiological event.
  • The ineffectiveness of salicylate in reducing the magnitude of Tc rise, unlike in rats, casts doubt on it being a true fever response.

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