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Updated: Feb 1, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Reirradiation in squamous cell head and neck cancer: recent developments and future directions
Johannes A Langendijk1, Jean Bourhis
1Department of Radiation Oncology, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands. j.a.langendijk@rt.umcg.nl
Purpose Of Review:
The purpose of this review is to highlight the most important developments in the management of recurrent or second primary head and neck carcinoma in previously irradiated areas by reirradiation that have been published in the medical literature in the past year.
Recent Findings:
Recent research indicates that long-term survival can be achieved in a proportion of patients using more advanced chemo-reirradiation protocols in the primary as well as in postoperative reirradiation setting. Despite the promising results with regard to locoregional tumour control and survival, treatment-related acute and late morbidity remains of major concern.
Summary:
As an increasing number of patients currently receive more effective initial treatment regimens, recurrent and second primary tumours in previously irradiated areas nowadays may represent a more radio-resistant population than reported in previous studies. Therefore, full-dose chemo-reirradiation should only be applied in well selected cases.
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