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Polypharmacy: when is it rational?

Sheldon H Preskorn1, Ronald L Lacey

  • 1University of Kansas School of Medicine-Wichita, Clinical Research Institute, Wichita, KS 67211, USA.

Journal of Psychiatric Practice
|April 7, 2007
PubMed
Summary
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This article explores rational polypharmacy in psychiatry, detailing its history and importance due to new psychotropic drugs. It provides 10 criteria for guiding the use of multiple medications for treating psychiatric conditions.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Polypharmacy, the use of multiple medications, has a history in psychiatric treatment.
  • Advances in psychotropic drug development increase the relevance of polypharmacy today.

Purpose of the Study:

  • To discuss the rational use of polypharmacy in psychiatric care.
  • To present criteria for guiding psychotropic polypharmacy.

Main Methods:

  • Historical overview of polypharmacy in psychiatry.
  • Presentation and detailed explanation of 10 criteria for rational psychotropic polypharmacy.
  • Inclusion of clinical examples to illustrate each criterion.

Main Results:

  • Identification of key considerations for when to use multiple medications for a single condition.

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  • Development of a framework for the judicious application of psychotropic polypharmacy.

    • Conclusions:

    • Rational polypharmacy is an increasingly important strategy in modern psychiatric treatment.
    • The provided criteria can aid clinicians in making informed decisions about psychotropic polypharmacy.