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Gastric true leiomyoma: computed tomographic findings and pathological correlation
Mi-Jung Lee1, Joon Seok Lim, Ji Eun Kwon
1Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Journal of Computer Assisted Tomography
|April 7, 2007
Summary
Computed tomography (CT) scans reveal that gastric true leiomyomas, which are CD117-negative, typically present as homogeneous, low-attenuation masses in the stomach cardia. These findings aid in diagnosing this rare benign tumor.
Area of Science:
- Gastroenterology
- Radiology
- Pathology
Background:
- Gastric true leiomyomas are rare mesenchymal tumors.
- Accurate diagnosis relies on histopathology and imaging characteristics.
Purpose of the Study:
- To describe the computed tomographic (CT) findings of true leiomyomas in the stomach.
- To correlate CT features with histopathological findings.
Main Methods:
- Retrospective review of CT scans from 11 patients with histopathologically confirmed gastric true leiomyomas.
- Analysis of tumor location, morphology (size, contour, growth pattern, enhancement), and ancillary findings (ulceration, calcification).
- Immunohistochemical analysis for CD117 (c-kit) negativity.
Main Results:
- All leiomyomas were located in the gastric cardia, with an average size of 36 mm.
- CT showed intraluminal (10/11) or extraluminal (1/11) growth, with lobulated (7/11) or smooth (4/11) margins.
- Lesions exhibited homogeneous, low contrast enhancement compared to the liver in most cases (10/11); one case had ulceration.
Conclusions:
- Gastric true leiomyomas are predominantly found in the cardia.
- CT typically demonstrates these tumors as homogeneous, low-attenuation masses.
- CD117 negativity is a key diagnostic feature on immunohistochemistry.