Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sclerosing cholangitis.

James Rl Maggs1, Roger W Chapman

  • 1Department of Gastroenterology, John Radcliffe Hospital, Oxford, UK.

Current Opinion in Gastroenterology
|April 7, 2007
PubMed
Summary
This summary is machine-generated.

Primary sclerosing cholangitis (PSC) research explores its immune basis and links to inflammatory bowel disease. New findings suggest potential therapies and diagnostic tools for this chronic liver condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determining the time to cholangiocarcinoma in pediatric-onset PSC-IBD.

Journal of pediatric gastroenterology and nutrition·2024
Same author

Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD.

Endoscopy international open·2024
Same author

Primary sclerosing cholangitis-A long night's journey into day.

Clinical liver disease·2022
Same author

Prevalence and long-term outcome of sub-clinical primary sclerosing cholangitis in patients with ulcerative colitis.

Liver international : official journal of the International Association for the Study of the Liver·2020
Same author

Review of primary sclerosing cholangitis with increased IgG4 levels.

World journal of gastroenterology·2020
Same author

Experience from the first UK inter-regional specialist multidisciplinary meeting in the diagnosis and management of IgG4-related disease.

Clinical medicine (London, England)·2020
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
Same journal

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
See all related articles

Area of Science:

  • Hepatology
  • Immunology
  • Gastroenterology

Background:

  • Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease.
  • It involves biliary tree strictures, potentially leading to cirrhosis and cholangiocarcinoma.
  • The exact cause of PSC is unknown, but it is considered immune-mediated.

Purpose of the Study:

  • To review current research on the etiopathogenesis and epidemiology of PSC.
  • To discuss advancements in diagnosing cholangiocarcinoma in PSC patients.
  • To explore associations with inflammatory bowel disease and autoimmune pancreatitis, and current medical therapies.

Main Methods:

  • Review of recent scientific literature on PSC.
  • Analysis of genetic polymorphism studies.

Related Experiment Videos

  • Evaluation of diagnostic techniques for cholangiocarcinoma.
  • Assessment of therapeutic interventions, including ursodeoxycholic acid derivatives.

    • Main Results:

    • Common inflammatory bowel disease polymorphisms are not linked to PSC susceptibility.
    • The roles of intercellular adhesion molecule-1 gene polymorphisms and CCR5 mutations in PSC require further investigation.
    • Elevated IgG4 levels in some PSC patients suggest a potential overlap with autoimmune pancreatitis and steroid responsiveness.
    • Biliary brush cytology aids cholangiocarcinoma diagnosis, but additional clinical indicators are needed.
    • Animal studies indicate 24-norursodeoxycholic acid may be more effective than ursodeoxycholic acid in reducing disease progression.

    Conclusions:

    • Genetic factors for PSC are complex and not fully understood.
    • Further research is needed to clarify the role of specific gene polymorphisms and the overlap with other autoimmune conditions.
    • Improved diagnostic markers for cholangiocarcinoma are necessary.
    • Clinical trials are required to validate the efficacy of novel therapeutic agents like 24-norursodeoxycholic acid in humans.