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Kinesigenic paroxysmal hemidyskinesia as the initial presentation of multiple sclerosis

Yara Dadalti Fragoso1, Mauro Gomes Araujo, Nilton Luiz Branco

  • 1Head, Department of Neurology, Universidade Metropolitana de Santos, SP, Brazil;

Medgenmed : Medscape General Medicine
|April 7, 2007
PubMed

Insights

Paroxysmal kinesigenic hemidyskinesia (PKD) is a rare initial symptom in multiple sclerosis (MS). This study details two cases of MS presenting with PKD, highlighting distinct lesion locations on MRI scans.

Area of Science:

  • Neurology
  • Neuroimmunology
  • Movement Disorders

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Paroxysmal dystonia is a rare neurological manifestation in MS patients.
  • Paroxysmal kinesigenic hemidyskinesia (PKD) is exceptionally uncommon as an initial presenting symptom in MS.

Observation:

  • This report describes two patients who presented with PKD as the first neurological symptom of MS.
  • One patient was diagnosed at age 18, the other at age 35.
  • Both patients exhibited distinct patterns of acute lesions on magnetic resonance imaging (MRI) associated with their PKD.

Findings:

  • The study identified specific MRI lesion locations in the subcortical parietal area, thalamus, and cervical spinal cord in relation to PKD in MS.
  • The findings suggest a potential correlation between specific lesion sites and the manifestation of PKD in early-stage MS.
  • These cases expand the understanding of the diverse clinical presentations of MS.

Implications:

  • Recognizing PKD as a potential initial symptom can aid in the early diagnosis of MS.
  • Understanding the neuroanatomical correlates of PKD in MS may inform future research into MS pathogenesis and treatment.
  • This case series contributes to the literature on rare movement disorders in the context of multiple sclerosis.

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