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Hyperthyroidism induced by iodinated glycerol.

J S Huseby1, S W Bennett, M E Hagensee

  • 1Department of Medicine and Respiratory Diseases, University of Washington, Seattle.

The American Review of Respiratory Disease
|December 1, 1991
PubMed
Summary
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Iodide-induced thyrotoxicosis can occur from iodinated glycerol, a medication for chronic obstructive pulmonary disease (COPD). Healthcare providers should be aware of this risk, especially in severe COPD patients with underlying thyroid conditions.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Pharmacology

Background:

  • Iodinated glycerol is used as an expectorant for symptomatic relief in chronic obstructive pulmonary disease (COPD).
  • Patients with severe COPD may present with subtle or overlooked hyperthyroid symptoms.
  • Preexisting thyroid disease can increase susceptibility to iodide-induced thyrotoxicosis.

Observation:

  • A case of thyrotoxicosis was observed following the administration of iodinated glycerol (Organidin).
  • The patient was using iodinated glycerol for the symptomatic management of chronic obstructive pulmonary disease.
  • Symptoms of hyperthyroidism were initially not recognized due to the severity of COPD.

Findings:

  • Iodinated glycerol can precipitate iodide-induced thyrotoxicosis.

Related Experiment Videos

  • Any iodinated expectorant carries a risk of inducing hyperthyroidism.
  • Patients with underlying thyroid conditions are particularly vulnerable.

    • Implications:

    • Clinicians should consider the potential for drug-induced hyperthyroidism when prescribing iodinated expectorants.
    • Vigilance is required for diagnosing hyperthyroidism in severe COPD patients, even with concurrent respiratory symptoms.
    • Alternative expectorants may be considered for patients with a history of thyroid dysfunction.