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[Celiac disease. Is its clinical pattern changing?]
J C Vitoria Cormenzana1, A Sojo Aguirre, M Corera Sánchez
1Departamento de Pediatría, Hospital de Cruces, Baracaldo, Vizcaya.
Anales Espanoles De Pediatria
|September 1, 1991
Summary
Celiac disease (CD) diagnosis in children often relies on intestinal biopsy. Modern diagnosis benefits from immunologic markers due to evolving, atypical symptoms in pediatric celiac disease.
Area of Science:
- Pediatric Gastroenterology
- Malabsorption Syndromes
- Immunology
Context:
- Celiac disease (CD) is a significant malabsorption syndrome in pediatrics.
- Diagnosis traditionally relies on peroral intestinal biopsy.
- Studied 178 patients with suspected CD between 1974-1988.
Purpose:
- To analyze the diagnostic trends and clinical presentations of pediatric celiac disease.
- To highlight the challenges in diagnosing CD with evolving symptomatology.
- To underscore the potential utility of immunologic markers.
Summary:
- 117 out of 178 suspected pediatric celiac disease cases were confirmed.
- Diagnosis occurred in the first year of life for 32.6% of patients.
- Observed a shift towards less apparent or atypical symptoms over time, alongside associated diseases.
Impact:
- Celiac disease presentation is changing, often with subtle or atypical symptoms.
- Diagnostic challenges necessitate exploring advanced diagnostic tools.
- Immunologic markers show promise in aiding the diagnosis of pediatric celiac disease.