Related Experiment Video
Updated: Jul 15, 2026
07:15
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
[Experimental models of cardiovascular disease]
A Gil Hernández1, M C Ramírez Tortosa, M C Aguilera García
1Departamento de Bioquímica y Biología Molecular II, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Granada, España. agil@ugr.es
Nutricion Hospitalaria
|April 10, 2007
Summary
This study reviews experimental models for cardiovascular disease, focusing on atherosclerosis. It covers dietary, genetic, and cellular models to understand disease mechanisms and test treatments.
Area of Science:
- Cardiovascular Science
- Pathophysiology
- Pharmacology
Context:
- Atherosclerosis is a complex inflammatory process central to many cardiovascular diseases.
- Understanding its mechanisms is crucial for developing effective treatments.
- Existing research relies on diverse experimental models.
Purpose:
- To review clinically relevant experimental models for studying cardiovascular disease, particularly atherosclerosis.
- To highlight models used for investigating pathophysiologic mechanisms.
- To assess the utility of models for evaluating nutritional and pharmacological interventions.
Summary:
- The work details experimental models for cardiovascular disease, emphasizing atherosclerosis.
- It includes dietary-induced, genetically modified (knock-out/knock-in, transgenic), and cell-based models.
- These models aid in understanding disease mechanisms and testing therapeutic agents.
Impact:
- Provides a comprehensive overview of atherosclerosis research models.
- Facilitates the selection of appropriate models for preclinical studies.
- Supports the development of novel nutritional and pharmacological strategies for cardiovascular disease.
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