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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))
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[Iron overload and arthropathy]

Gérard Chalès1, Pascal Guggenbuhl, Yves Pawlotsky

  • 1Service de rhumatologie, hôpital Sud, 35203 Rennes Cedex 2. gerard.chales@chu-rennes.fr

La Revue Du Praticien
|April 10, 2007
PubMed

Arthropathy is a major and distinctive manifestation of hemochromatosis, resembling degenerative joint disease with involvement of unusual articular sites, almost identical to the arthropathy in calcium pyrophosphate dihydrate crystals deposition disease (chondrocalcinosis), associated with osteoporosis. Hemochromatosis is the clinical condition of iron overload; it can be genetic or secondary. It is important to know how to diagnose early genetic hemochromatosis since it is a frequent, life-threatening and treatable condition. Early bio-clinical symptoms are weakness, arthralgias and increase of serum tranferrin saturation.

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