Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute splenic sequestration in female children with sickle cell disease in the North of Jordan.

Journal of tropical pediatrics·2006
Same author

Hypothalamic-pituitary-gonadal function in adolescent females with beta-thalassemia major.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2005
Same author

Caries risk in patients with thalassaemia major.

International dental journal·2001
Same author

Exhaled nitric oxide levels in exacerbations of asthma, chronic obstructive pulmonary disease and pneumonia.

Saudi medical journal·2001
Same author

Dental discoloration: an overview.

Journal of esthetic dentistry·2000
Same author

Effect of desferrioxamine in acute haemolytic anaemia of glucose-6-phosphate dehydrogenase deficiency.

Acta haematologica·1999

Related Experiment Video

Updated: Jul 15, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Pulmonary function tests in children with beta-thalassemia major.

F M Abu-Ekteish1, H S Al-Rimawi, M K Al-Ali

  • 1Department of Pediatrics, Jordan University of Science & Technology, Irbid, Jordan. faisal@just.edu.jo

Chronic Respiratory Disease
|April 10, 2007
PubMed
Summary

Children with beta-thalassemia major often show restrictive lung dysfunction. This study found predominantly restrictive patterns, with some obstructive patterns and diffusion impairment, but no link to ferritin levels.

Related Experiment Videos

Last Updated: Jul 15, 2026

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Area of Science:

  • Pediatric Pulmonology
  • Hematology
  • Thalassemia Research

Background:

  • Lung function abnormalities are recognized complications of thalassemia, yet previous study findings on pulmonary function have been inconsistent.
  • Understanding the specific types of lung impairment in children with thalassemia is crucial for effective management.

Purpose of the Study:

  • To characterize the patterns of lung impairment in children diagnosed with beta-thalassemia major.
  • To investigate the relationship between serum ferritin levels and lung function abnormalities in this pediatric population.

Main Methods:

  • Pulmonary function tests, including spirometry, total lung capacity (TLC), diffusing capacity of the lung for carbon monoxide (DL(CO)), and arterial blood gases, were performed on 40 children with beta-thalassemia major.
  • Serum ferritin levels were measured to assess their correlation with observed lung function deficits.

Main Results:

  • A predominantly restrictive lung function pattern was identified in 35% of patients, characterized by reduced RV, FVC, TLC, and PEF.
  • Obstructive airway disease was present in 15% of patients, and impaired diffusion capacity (DL(CO) < 80%) was observed in 25%.
  • No significant correlation was found between the severity of lung dysfunction (restrictive or obstructive) and serum ferritin levels, although age and ferritin showed a positive correlation.

Conclusions:

  • Children with beta-thalassemia major exhibit a predominant pattern of restrictive lung dysfunction, potentially linked to pulmonary parenchymal changes.
  • The etiology of the obstructive pattern observed in a subset of patients requires further investigation.
  • Serum ferritin levels do not appear to correlate with the degree of lung impairment in thalassemic children.