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CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease
Brent E Palmer1, Douglas G Mack, Allison K Martin
1Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA.
The Journal of Allergy and Clinical Immunology
|April 10, 2007
Summary
CD57 expression on T cells in the lungs, but not blood, correlates with chronic beryllium disease severity. Higher CD57 indicates lung inflammation and may signal disease progression.
Area of Science:
- Immunology
- T-cell biology
- Pulmonary medicine
Background:
- Surface phenotype of T cells is linked to function, but this is poorly understood for antigen-specific CD4(+) T cells in target organs.
- Chronic beryllium disease (CBD) involves lung inflammation and T-cell responses to beryllium.
Purpose of the Study:
- To investigate the relationship between CD57 expression (a marker of T-cell senescence) and CBD severity.
- To characterize phenotypic and functional differences of beryllium-specific CD4(+) T cells in the lung versus blood.
Main Methods:
- Quantified CD57 expression on beryllium-responsive, cytokine-producing CD4(+) T cells in blood and bronchoalveolar lavage (BAL) fluid.
- Studied 17 beryllium-sensitized and 20 CBD subjects.
Main Results:
- CD57 expression was higher on lung CD4(+) T cells (BAL) compared to blood cells in both sensitized and CBD subjects.
- Increased CD57 on BAL CD4(+) T cells correlated with lymphocytic alveolitis, a marker of lung inflammation.
- CD57 expression was associated with more differentiated memory T cells and reduced proliferative capacity.
- No difference in CD57 expression was observed between beryllium-specific CD4(+) T cells producing only IFN-gamma versus those producing both IFN-gamma and IL-2.
Conclusions:
- CD57 expression on CD4(+) T cells is a valuable phenotypic marker for assessing lung inflammation in CBD.
- CD57 may serve as an indicator of disease severity and functional status of the T-cell compartment in CBD.
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