[Inflammation, adaptive regeneration and dysregeneration (intercellular interaction analysis)]

Inflammation, regeneration and fibrosis are inseparable components of the adaptive tissue response to damage. Systemic analysis indicates that this reaction is brought about due to the cooperative interaction of the connective tissue and blood cells (neutrophils, labrocytes, thrombocytes, macrophages, lymphocytes, fibroblasts) between each other, with intercellular matrix (collagen, fibronectin, proteoglycans) and organ parenchyma on the basis of feedback mechanisms. The role of the "cell orchestra conductor" changes at different stage of reaction; macrophage-fibroblast interaction is the most important in the cooperation between inflammation and regeneration. The breakdown of the homeostatic autoregulatory mechanisms (particularly those of intercellular and intertissue interaction) results in the disturbance of standard reactions, disintegration of inflammation and regeneration, chronicity of inflammatory reactions, incomplete regeneration, progressing sclerosis, formation of deficient granulation and fibrous tissue, tendency to the secondary destruction. The process loses the adaptive character and the notion of "dysregeneration" is introduced for its characteristics.