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Progesterone and oestradiol increase cytosolic Ca2+ in single rat hepatocytes
A Sanchez-Bueno1, M J Sancho, P H Cobbold
1Department of Human Anatomy and Cell Biology, University of Liverpool, U.K.
The Biochemical Journal
|November 15, 1991
Abstract:
Progesterone (300-400 microM) and oestradiol (25-200 microM) induce a prompt rise in the cytosolic free Ca2+ concentration (free Ca) in single rat hepatocytes, but testosterone, cortisol and dexamethasone do not. These increases are dependent on the presence of extracellular Ca2+. Both progesterone and oestradiol block phenylephrine-induced free Ca oscillations. These data suggest a certain specificity of the response of free Ca to steroids and may explain some of the non-genomic effects of these steroids on hepatocytes.