Related Experiment Videos
Comparison of the domain-level organization of starch hydrolases and related enzymes
H M Jespersen1, E A MacGregor, M R Sierks
1Department of Chemistry, Carlsberg Laboratory, Copenhagen Valby, Denmark.
The Biochemical Journal
|November 15, 1991
Abstract:
Structure-prediction and hydrophobic-cluster analysis of several starch hydrolases and related enzymes indicated the organization of eleven domain types. Most enzymes possess a catalytic (beta/alpha)8-barrel and a smaller C-terminal domain as seen in crystal structures of alpha-amylase and cyclodextrin glucanotransferase. Some also have a starch-granule-binding domain. Enzymes breaking or forming endo-alpha-1,6 linkages contain domains N-terminal to the (beta/alpha)8-barrel.