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In vitro comparison of two bioartificial liver support systems: MELS CellModule and AMC-BAL.

P P C Poyck1, G Pless, R Hoekstra

  • 1Department of Surgery (Surgical Laboratory), Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands.

The International Journal of Artificial Organs
|April 10, 2007
PubMed
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This study compared two bioartificial liver (BAL) support systems, MELS CellModule and AMC-BAL, in vitro. Both systems demonstrated comparable hepatocyte function over seven days, indicating similar clinical potential.

Area of Science:

  • Hepatology
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Comparing clinically applied bioartificial liver (BAL) support systems is challenging due to variations in hepatocyte function and clinical outcomes.
  • Standardized in vitro comparisons are crucial for evaluating the efficacy of different BAL technologies.

Purpose of the Study:

  • To conduct an in vitro comparison of two clinically applied bioartificial liver systems: Modular Extracorporeal Liver Support (MELS) CellModule and AMC-bioartificial liver (AMC-BAL).
  • To assess and compare the hepatocyte-specific functions and overall performance of both BAL systems over a 7-day culture period.

Main Methods:

  • Both BAL systems were loaded with 10 billion freshly isolated porcine hepatocytes.
  • Hepatocyte function was cultured for 7 days and tested on days 1, 2, 4, and 7.

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  • Key parameters assessed included lidocaine elimination, ammonia elimination, and lactate dehydrogenase (LDH) release.

    • Main Results:

    • An average decrease of 9.7% in hepatocyte-specific functions was observed over the 7-day period for both systems.
    • AMC-BAL showed significantly higher lidocaine elimination on days 1 and 2.
    • AMC-BAL demonstrated a significantly higher trend in ammonia elimination over 7 days, while MELS CellModule exhibited significantly lower LDH release on day 7.

    Conclusions:

    • This in vitro study provides the first direct comparison of the MELS CellModule and AMC-BAL systems.
    • Both clinically applied BAL systems exhibit comparable overall functional capacity over a 7-day period.
    • Minor differences in specific metabolic functions were observed, suggesting potential areas for system-specific optimization.