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[Comparative immediate results after the use of several lyophilized BCG vaccines]
Insights
BCG vaccination in children using experimental Romanian and French strains showed varied tuberculin sensitivity. Standard BCG vaccine induced longer-lasting sensitivity compared to experimental vaccines.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- Bacille Calmette-Guérin (BCG) vaccination is a primary strategy for tuberculosis prevention.
- Evaluating novel BCG vaccine strains is crucial for enhancing tuberculosis control efforts.
Purpose of the Study:
- To compare the immunogenicity of experimental BCG vaccine strains (Romanian and French) against a standard BCG vaccine.
- To assess tuberculin sensitivity following intradermal vaccination in a pediatric population.
Main Methods:
- 1928 children received intradermal BCG vaccinations.
- Vaccines included standard BCG (Cantacuzino Institute) and two experimental strains (Romanian and French).
- Tuberculin sensitivity was evaluated 8-10 weeks post-vaccination using purified protein derivative (PPD).
Main Results:
- BCG vaccination with standard doses resulted in tuberculin induration diameters ranging from 13.23 mm to 16.27 mm.
- Experimental vaccines, administered in two doses, induced smaller tuberculin induration diameters, ranging from 8.6 mm to 12.28 mm.
- Differences in tuberculin sensitivity duration were observed between the standard and experimental BCG vaccines.
Conclusions:
- The standard BCG vaccine demonstrated a more robust and potentially longer-lasting tuberculin sensitivity compared to the experimental strains.
- Further research is warranted to optimize dosing and evaluate the long-term efficacy of these experimental BCG vaccine strains.
Abstract:
A number of 1928 children were vaccinated intradermally with 12 series of BCG vaccine produced by the Cantacuzino Institute and 2 experimental vaccines, prepared in the same laboratory by the same current technique, i.e. a Romanian strain and a French strain, lot 1173 P2. With the experimental vaccines 2 doses were used, with the other vaccines a single standard dose of 0.10 mg. Appraisal of tuberculin sensitivity 8-10 weeks after vaccination showed differences in tuberculin duration, varying between 13.23 mm and 16.27 mm in diameter with the selected vaccines (using 2 units PPD) and were much smaller (8.6 mm -- 12.28 mm) with the operational series of vaccines.