Related Experiment Video
Updated: Jul 15, 2026

A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates
Published on: August 21, 2018
Long-distance radical cation hopping in DNA: the effect of thymine-Hg(II)-thymine base pairs
Joshy Joseph1, Gary B Schuster
1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Abstract:
Thymine-Hg(II)-thymine base pairs have been incorporated in an oligonucleotide duplex to study their effect on DNA-mediated charge transport. The introduction of a formally charged Hg atom inside the DNA base core does not significantly alter the charge hopping and trapping properties, as discussed in this paper. Hg(II) replaces the protons normally found on thymines within the complex and acts like a "big proton" in terms of its role in DNA charge transport.
Related Concept Videos
DNA Base Pairing
DNA Base Pairing
Spontaneous and Induced Mutations
Radical Reactivity: Overview
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group with both...
Homologous Recombination

