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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

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Related Experiment Video

Updated: Jul 15, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Rheumatic manifestations of lymphoproliferative disorders.

U Kiltz¹, J Brandt, J Zochling

¹Rheumazentrum Ruhrgebiet, St. Josefs-Krankenhaus, Herne, Germany. kiltz@rheumazentrum-ruhrgbiet.de

Clinical and Experimental Rheumatology

|April 10, 2007

Summary

Rheumatologists should consider lymphoproliferative disorders in patients with unexpected arthritis, especially when treated with disease-modifying antirheumatic drugs. Early biopsy can help rule out coexistent neoplasia.

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Area of Science:

Rheumatology
Oncology
Hematology

Background:

The link between rheumatic diseases and malignancy risk is established.
Musculoskeletal symptoms can overlap with lymphoproliferative disorders.

Observation:

Three cases of inflammatory joint disease patients treated with disease-modifying antirheumatic drugs (DMARDs) who developed lymphoproliferative disorders are presented.
Cases highlight diagnostic challenges, rare lymphoma types, and the sarcoidosis-lymphoma syndrome.

Findings:

Differentiating musculoskeletal symptoms of lymphoproliferative disease from rheumatic disease, particularly under DMARDs and biologics, is difficult.
One patient was misdiagnosed with seronegative rheumatoid arthritis (RA) presenting a rare lymphoma.
Another patient exemplified the sarcoidosis-lymphoma syndrome with oligoarthritis.

Implications:

Rheumatologists face challenges in managing rheumatologic manifestations of lymphoproliferative disorders.
Histologic biopsy is recommended for patients with unexplained arthritis to exclude concurrent neoplasia.
Further research is needed to establish definitive diagnostic and management guidelines.