Related Experiment Video
Updated: Jul 15, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities
Che-Chen Wu1, Chien-Fang Peng, Ian-Lih Tsai
1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
Abstract:
Engelharquinone (1), engelharquinone epoxide (2), engelharolide (3), and engelhardic acid (4), were isolated as naturally occurring products from a plant source, Engelhardia roxburghiana together with 20 previously known compounds, four of which were hitherto not known as plant constituents. Their structures were identified by means of spectroscopic analysis. A biological evaluation showed that three of the previously isolated antitubercular constituents [(-)-4-hydroxy-1-tetralone, 3-methoxyjuglone and engelhardione] and engelharquinone (1) exhibited moderate antitubercular activity against Mycobacterium tuberculosis 90-221387.
Related Concept Videos
Anthelminthic Agents
Antiprotozoal Agents
Drugs that Destabilize Microtubules
Antifungal Agents
Drugs that Stabilize Microtubules
