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Updated: Jul 15, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
Genome-wide SNP analysis in cancer: leukemia shows the way
Yingzi Wang1, Scott A Armstrong
1Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
The application of novel genetic/genomic technologies to the study of acute leukemia has frequently been a proving ground for such approaches in cancer. Recent development of high-resolution single-nucleotide polymorphism (SNP) arrays allows detailed assessment of the genomes in cancer cells. A recent study by Mullighan et al. uses SNP arrays to assess copy number alterations in a large group of childhood acute lymphoblastic leukemias and demonstrates frequent mutation of genes encoding transcription factors important for B cell development. These studies not only provide information about the multistep development of leukemia, but also demonstrate the potential for this approach in other cancers.
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