Related Experiment Video
Updated: Jul 15, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy
Aubert Agostini1, Karina Blanc, Isabelle Ronda
1Service de Gynécologie Obstétrique, Hôpital La Conception, Marseille, France. aagostini@mail.ap-hm.fr <aagostini@mail.ap-hm.fr>
Abstract:
Because early prediction of clinical outcome (one or more injections or surgery) of methotrexate treatment of ectopic pregnancy could ease the intensity of follow-up and patient compliance required, we studied the relationship between the change in hCG levels after methotrexate injection and outcome in 129 consecutive patients. A 20% decline in hCG levels between days 1 and 4 during methotrexate treatment has a positive predictive value of 97%.