Related Experiment Video

Updated: Jul 15, 2026

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
10:26

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles

Published on: November 1, 2017

Improved biochemical strategies for targeted delivery of taxoids

Thota Ganesh1

  • 1Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA. tganesh@emory.edu

Bioorganic & Medicinal Chemistry
|April 10, 2007
PubMed

Insights

Novel prodrug and drug targeting strategies enhance paclitaxel and docetaxel efficacy against cancer. These approaches aim to overcome limitations like toxicity and poor solubility for improved chemotherapy.

Area of Science:

  • Oncology
  • Pharmaceutical Chemistry
  • Drug Delivery

Background:

  • Paclitaxel (Taxol) and docetaxel (Taxotere) are vital anti-cancer drugs.
  • Clinical use is hampered by systemic toxicity, low solubility, and resistance.
  • Improved delivery and reduced side effects are critical for taxoid chemotherapy.

Purpose of the Study:

  • To review biochemical strategies for enhancing taxoid efficacy.
  • To explore prodrug and drug targeting approaches for cancer treatment.
  • To assess the biological effectiveness of novel taxoid chemotherapeutics.

Main Methods:

  • Literature review of prodrug and drug targeting strategies for taxoids.
  • Analysis of biochemical design principles targeting cancer cell abnormalities.
  • Evaluation of reported biological efficacies of developed taxoid derivatives.

Main Results:

  • Various prodrug and drug targeting strategies have been developed.
  • These strategies aim to improve oral bioavailability and tumor-specific delivery.
  • Abnormalities in cancer cells are leveraged for targeted drug delivery.

Conclusions:

  • Prodrug and targeted delivery strategies offer promising solutions to taxoid limitations.
  • Biochemical approaches can enhance the therapeutic index of paclitaxel and docetaxel.
  • Further research into these strategies could lead to more effective cancer treatments.

More Related Videos

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice08:41

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice

Published on: October 27, 2014

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...