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Updated: Jul 15, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
[Risk factors for total prosthetic joint infection. Case-control study]
Alfredo Jover-Saénz1, Fernando Barcenilla-Gaite, Joan Torres-Puig-Gros
1Unidad Funcional para el Control de la Infección Nosocomial, Servicio de Medicina Interna, Hospital Universitario Arnau de Vilanova, Lleida, España. ajover@arnau.scs.es
High surgical risk scores and post-operative complications significantly increase the risk of knee and hip prosthesis infections. Careful patient assessment and management are crucial for preventing these infections.
Area of Science:
- Orthopedic surgery
- Infectious disease epidemiology
Context:
- Total joint arthroplasty is a common procedure for end-stage joint disease.
- Prosthetic joint infections (PJIs) are a serious complication, leading to increased morbidity and healthcare costs.
Purpose:
- To identify key risk factors associated with infection following knee and hip total prosthesis surgery.
Summary:
- A 10-year case-control study analyzed 1,666 joint implants.
- Infection risk factors identified include a high surgical risk rate (National Nosocomial Infections Surveillance score ≥ 2) and non-infectious post-operative complications.
- The overall infection rate was 2.4%, with Gram-positive cocci being the predominant pathogens (63%).
Impact:
- Findings highlight the importance of the National Nosocomial Infections Surveillance score and managing non-infectious complications to mitigate PJI risk.
- This research aids in refining patient selection and perioperative management strategies to improve outcomes in total joint arthroplasty.
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