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Related Experiment Video

Updated: Jul 15, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Immunotherapy by allogeneic stem cell transplantation.

Olle Ringdén¹

¹Division of Clinical Immunology, Karolinska Institutet, Karolinska University, Hospital, Huddinge, SE-141 86 Stockholm, Sweden.

Advances in Cancer Research

|April 11, 2007

Summary

Allogeneic stem cell transplantation (ASCT) is now a standard therapy for immunohematopoietic disorders. Research is exploring ways to improve outcomes by managing graft-versus-host disease (GVHD) and leveraging the graft-versus-cancer effect.

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

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Published on: May 27, 2011

Area of Science:

Hematology
Immunology
Oncology

Background:

Allogeneic stem cell transplantation (ASCT) has evolved into a established treatment for various immunohematopoietic disorders.
Graft-versus-host disease (GVHD) remains a significant challenge, despite its therapeutic benefits.

Purpose of the Study:

To review the advancements and future prospects of allogeneic stem cell transplantation.
To discuss strategies for mitigating GVHD and enhancing the graft-versus-leukemia/cancer effect.

Main Methods:

Review of current literature on ASCT, GVHD management, and graft-versus-cancer mechanisms.
Analysis of novel therapeutic approaches including donor lymphocyte infusions and mesenchymal stem cells.

Main Results:

Standard GVHD prophylaxis involves calcineurin inhibitors and methotrexate, with modulation potentially improving survival.
Killer cell immunoglobulin-like receptor incompatibility may reduce relapse risk in myeloid leukemia.
Donor lymphocyte infusions and mesenchymal stem cells show promise for managing relapse and GVHD.

Conclusions:

ASCT offers a potent graft-versus-leukemia/cancer effect applicable to hematologic malignancies and solid tumors.
Ongoing research into immunomodulation and cellular therapies suggests a promising future for ASCT.