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Pulmonary complications of haematopoietic cell transplantation in children

Peter H Michelson1, Rakesh Goyal, Geoffrey Kurland

  • 1Division of Pediatric Pulmology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. peter.michelson@chp.edu <peter.michelson@chp.edu>

Paediatric Respiratory Reviews
|April 11, 2007
PubMed

Insights

Pulmonary complications remain a significant challenge after paediatric hematopoietic cell transplantation, impacting survival. This review covers infectious and non-infectious causes, diagnosis, and treatment to improve patient outcomes.

Area of Science:

  • Pediatric Hematology
  • Pulmonology
  • Transplantation Medicine

Background:

  • Hematopoietic cell transplantation (HCT) has advanced significantly, yet pulmonary complications remain a major cause of morbidity and mortality.
  • These complications affect both adult and pediatric recipients and persist even in specialized centers.

Purpose of the Study:

  • To review common pediatric pulmonary complications following HCT.
  • To discuss infectious and non-infectious etiologies, clinical presentations, evaluation, and therapeutic strategies.
  • To examine recent treatment advances and explore future therapies for improved long-term survival.

Main Methods:

  • Comprehensive literature review of pediatric pulmonary complications post-HCT.
  • Analysis of infectious and non-infectious etiologies and their management.
  • Evaluation of current treatment paradigms and emerging therapeutic approaches.

Main Results:

  • Pulmonary complications are a critical limitation in pediatric HCT efficacy.
  • Both infectious and non-infectious causes contribute to significant post-transplant complications.
  • Optimizing immunosuppression and diagnostic/treatment protocols are crucial.

Conclusions:

  • Addressing pulmonary complications requires a multifaceted approach, including careful management of immunosuppression.
  • Continued research into novel diagnostic and therapeutic strategies is essential for improving outcomes.
  • Future therapies hold promise for enhancing long-term survival in pediatric HCT recipients.

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