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Related Experiment Video

Updated: Jul 15, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

The centrosome opens the way to mitosis.

Renata Basto¹, Jonathon Pines

¹Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR United Kingdom. r.basto@gurdon.cam.ac.uk

Developmental Cell

|April 11, 2007

Summary

Centrosomes promote nuclear envelope breakdown during mitosis, independent of microtubule nucleation. They act as spatial regulators for Aurora A kinase activation, crucial for chromosome-microtubule interactions.

Area of Science:

Cell Biology
Molecular Biology
Genetics

Background:

Mitosis requires chromosome-microtubule interactions, necessitating nuclear envelope disassembly in prophase.
Centrosomes are key organelles in cell division, traditionally known for microtubule nucleation.

Purpose of the Study:

To investigate the role of centrosomes in nuclear envelope breakdown during mitosis.
To elucidate the mechanism by which centrosomes influence this process, particularly concerning Aurora A kinase.

Main Methods:

Experimental cell biology techniques were employed.
Studies focused on centrosome function and Aurora A kinase localization and activity.

Main Results:

Centrosomes were found to promote nuclear envelope breakdown.

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Related Experiment Videos

Last Updated: Jul 15, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

Imaging Centrosomes in Fly Testes

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Published on: August 13, 2016

This function is independent of the centrosome's role in microtubule nucleation.

The centrosome acts as a spatial regulator for Aurora A kinase activation.

Conclusions:

Centrosomes play a critical, previously unrecognized role in regulating nuclear envelope breakdown.
This regulation is achieved through spatial control of Aurora A kinase, impacting mitotic progression.