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Published on: September 24, 2021
Pacemaker infections: a 10-year experience
Andrei Catanchin1, Challon J Murdock, Eugene Athan
1Department of Cardiology, Barwon Health (Geelong Hospital), Geelong, Vic. 3220, Australia. andrei.catanchin@gmail.com
Background:
Infection is a major complication of pacemaker and defibrillator (PPM/ICD) implantation. The experience in an Australian regional centre is reported.
Methods:
Ten years' (1994-2004) cases of PPM/ICD infection retrospectively analysed and compared to overall insertion data; management and outcomes examined.
Results:
A total 39 cases (79.5% male, median age 71.3 years) identified, 24 in the primary centre where 1481 procedures performed (infection rate 1.6%). Patients with infection had average 2.2 procedures performed (odds ratio for infection if >1 procedure=4.7); 14 (36%) first implantations, 35 (90%) pacemakers, 11 (28%) recurrent. No difference in operation duration or difficulty between infected and non-infected cases. Infection in 18 cases (46%) involved lead/s, 16 (41%) generator and 5 (13%) both. Median time to presentation was 7.9 months. Echocardiography demonstrated lead vegetations in 8 cases. Organisms identified in 25 (64%)-92% Staphylococci (65% S. aureus); blood cultures positive in 18. PPM/ICD removed in 26 (67%), including lead/s in 89%; average hospital stay 37 days. One death attributable to PPM/ICD infection (mortality 2.6%), median follow-up 29.3 months.
Conclusions:
A PPM/ICD infection rate of 1.6% (endocarditis 0.3%) demonstrated. Second and subsequent procedures carried almost 5 times greater infection risk.
Insights
Pacemaker and defibrillator infections occur at a 1.6% rate, with subsequent procedures significantly increasing infection risk. Early detection and management are crucial for patient outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Device Technology
Background:
- Device infection is a significant complication following pacemaker and implantable cardioverter-defibrillator (PPM/ICD) implantation.
- This study reports the experience and outcomes of PPM/ICD infections in an Australian regional center.
Purpose of the Study:
- To analyze the incidence, characteristics, management, and outcomes of PPM/ICD infections.
- To identify risk factors associated with PPM/ICD infections.
Main Methods:
- Retrospective analysis of 39 PPM/ICD infection cases over a ten-year period (1994-2004).
- Comparison of infection data with overall device insertion data.
- Examination of patient demographics, procedural history, clinical presentation, microbiological findings, management strategies, and patient outcomes.
Main Results:
- The overall PPM/ICD infection rate was 1.6% (endocarditis 0.3%).
- Patients undergoing multiple procedures had a significantly higher risk of infection (OR=4.7).
- Staphylococci, particularly Staphylococcus aureus, were the most common pathogens identified.
Conclusions:
- The incidence of PPM/ICD infection in this cohort was 1.6%.
- Performing a second or subsequent procedure increased the risk of infection nearly fivefold.
- Prompt diagnosis and intervention are essential for managing PPM/ICD infections and improving patient outcomes.
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