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Related Concept Videos

Dense Connective Tissue01:13

Dense Connective Tissue

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Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
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In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
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Phase Transitions: Sublimation and Deposition02:33

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Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
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Role of Microtubules in Cell Wall Deposition01:02

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Microtubules are small hollow tubes in eukaryotic cells. The cell wall microtubules are polymerized dimers of two globular proteins, α-tubulin and β-tubulin, two globular proteins. With a diameter of about 25 nm, microtubules are the widest components of the cytoskeleton. They help the cell resist compression and provide a track along which vesicles move through the cell or pull replicated chromosomes to opposite ends of a dividing cell. Microtubules go through quick cycles of...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Principles of Disease Surveillance01:26

Principles of Disease Surveillance

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
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Dense deposit disease: new insights.

Patrick D Walker1

  • 1Nephropathology Associates, Little Rock, Akansas 72211, USA. walkerpd@kidneybx.com

Current Opinion in Nephrology and Hypertension
|April 11, 2007
PubMed
Summary

Dense deposit disease, a rare condition affecting children, involves complex complement system dysregulation. Recent advances in genetic mapping and complement inhibitors offer hope for improved therapeutic strategies.

Area of Science:

  • Nephrology
  • Genetics
  • Immunology

Background:

  • Dense deposit disease (DDD) is a rare, severe pediatric kidney disease.
  • Understanding its pathophysiology, histopathology, and associations with other conditions like macular degeneration and acquired partial lipodystrophy is crucial.

Purpose of the Study:

  • To review recent advancements in the understanding of DDD.
  • To explore new insights into its pathophysiology, histopathology, and potential therapeutic targets.

Main Methods:

  • Review of current literature on dense deposit disease.
  • Analysis of histopathological findings and genetic associations.
  • Evaluation of emerging therapeutic strategies.

Main Results:

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  • DDD exhibits diverse histopathological patterns, with only 25% showing membranoproliferative features.
  • Genetic factors influencing complement regulatory proteins and alternative pathway dysregulation are increasingly recognized.
  • Haplotype mapping identifies complement factor H phenotypes linked to DDD development.

Conclusions:

  • Significant progress has been made in understanding DDD pathology and pathophysiology.
  • Genetic mapping and novel complement inhibitors are paving the way for better patient care.