Related Experiment Videos
Treatment options for prehypertension
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8899, USA. Shawna.Nesbitt@utsouthwestern.edu
Prehypertension treatment is evolving. The Trial of Preventing Hypertension (TROPHY) shows pharmacologic intervention, specifically angiotensin receptor blockers, is a safe option to prevent hypertension.
Area of Science:
- Cardiology
- Hypertension Research
Background:
- Prehypertension is a recognized stage of blood pressure.
- Established treatment standards for prehypertension are lacking.
- Focus has been on nonpharmacologic interventions.
Purpose of the Study:
- To review treatment considerations for prehypertension.
- To highlight the significance of pharmacologic interventions.
Main Methods:
- Review of previous approaches to prehypertension.
- Analysis of the Trial of Preventing Hypertension (TROPHY) study.
Main Results:
- The TROPHY study is the first to investigate pharmacologic intervention for prehypertension.
- Angiotensin receptor blockers demonstrated safety and tolerability in the trial.
Conclusions:
- Pharmacologic treatment, particularly with angiotensin receptor blockers, offers a new option for managing prehypertension.
- The TROPHY study paves the way for further research into prehypertension treatments.
Related Concept Videos
Hypertension IV: Drug Therapy and Lifestyle Modifications
Hypertension V: Nursing Management
Hypertension III: Clinical Manifestations and Diagnostic Studies
Atherosclerosis III: Management
Hypertension and Regulation of Blood Pressure
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...