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Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

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Nuclear imaging in cancer theranostics.

S Del Vecchio¹, A Zannetti, R Fonti

¹Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy. delvecc@unina.it

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of

|April 11, 2007

Summary

Theranostics combines diagnostic tests with therapies to identify patients who will benefit from specific treatments. This approach accelerates drug development, particularly in oncology, by improving patient selection for clinical trials.

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Area of Science:

Oncology
Nuclear Medicine
Pharmacology

Background:

Theranostics integrates diagnostic testing with therapeutic interventions.
This approach identifies patients likely to benefit from, or experience adverse effects from, specific drugs.
The drug development process can be accelerated by enriching patient populations in clinical trials.

Purpose of the Study:

To review the role of non-invasive nuclear imaging in cancer theranostics.
To highlight examples of nuclear imaging procedures coupled with specific therapies.
To focus on imaging methods for identifying patients who will benefit from targeted therapy or fail standard treatment.

Main Methods:

Review of existing literature on theranostics and nuclear imaging in oncology.
Identification of prominent examples of theranostic nuclear imaging procedures.
Analysis of the contribution of non-invasive imaging to patient selection for cancer therapies.

Main Results:

Theranostics is a promising avenue adopted by many drug companies for drug development.
Nuclear medicine provides historical and practical foundations for theranostic strategies.
Non-invasive nuclear imaging offers significant contributions to cancer theranostics.

Conclusions:

The adoption of theranostic concepts by regulatory authorities signifies progress in molecularly targeted drug development.
Oncology presents strong clinical evidence for the necessity of linking diagnostics with therapeutics.
Nuclear imaging procedures are crucial for identifying patient eligibility for targeted therapies and predicting treatment response.