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Cell-based Flow Cytometry Assay to Measure Cytotoxic Activity
Published on: December 17, 2013
Mathematical models of cytotoxic T-lymphocyte killing
Roland R Regoes1, Andrew Yates, Rustom Antia
1Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland.
Immunology and Cell Biology
|April 11, 2007
Abstract:
By killing infected host cells, cytotoxic T lymphocytes (CTL) mediate an important defense mechanism against viruses and other intracellular pathogens. Quantitative aspects of this killing process have been studied for several decades in vitro. More recently, methods have been developed to measure the timescales of CTL killing in vivo. Here, we review the estimates of kinetic rates involved in CTL killing which were obtained in these studies, and elaborate on the differences between them.

